Daptomycin ReadyMade™ Solution D108-10x0.5ML

产品介绍

Daptomycin ReadyMade™ Solution is provided as a sterile-filtered solution formulated in ~ 10% β-cyclodextrin saline solution at a concentation of  1 mg/ml.

Daptomycin is a unique 13-residue cyclic anionic lipopeptide antibiotic derived from Streptomyces roseosporus that is effective against Gram-positive bacteria. This holoenzyme is composed of three subunits, encoded by the dptA, dptBC, and dptD genes, each responsible for incorporating particular amino acids into the peptide. The cloned dpt gene cluster allows study of Daptomycin biosynthesis and discovery of novel lipopetides through pathway engineering.

Resarch has shown that Daptomycin requires calcium to form a micellar structure in solution and to bind to bacterial model membranes.