Delamanid D110-50MG

产品介绍

Delamanid is a dihydro-nitroimidazooxazole derivative. It is an antimicobacterial compound used for Mycobacterium tuberculosis (Mtb), the causal agent of tuberculosis. Delamanid is a pro-drug which is activated ty the enzyme deazaflavin dependent nitroreductase (Rv3547). It can be used in preclinical models such as the zebrafish-embryo model by providing an early in vivo infection model for compound evaluation. Further research is needed in order to translate the results seen in zebrafish models. Preclinical and clinical studies have shown that it has high potency, lower risk for interactions with other compounds, and a favorable toxicity profile. Approved in 2014 in Europe and Japan, Delamanid is marketed by Otsuka Pharmaceutical.

Delamanid is soluble in DMSO but practically insoluble in water.