Amphotericin B USP A007-1G
- 价格：￥2,944.00 元
产品介绍
Amphotericin B, USP (syn: Fungizone) is a polyene macrolide aminoglycoside broad-spectrum antimycotic. This bioactive natural product was isolated from soil collected from Orinoco River (Venezuela) in 1955 and identified as Streptomyces nodosus by Squibb Institute for Medical Research. It is used to control contamination from fungi, viruses and protozoa and a common media selective agent to inhibit the growth of background fungi. It also has immunomodulatory properties.
In the face of the global COVID-19 pandemic, the Centers for Disease Control (CDC) Standard Operating Procedure (SOP) DSR-052-04 includes the addition of Amphotericin B to viral transport media for SARS-CoV2 samples.
Amphotericin B, USP is soluble in DMSO but is practically insoluble in water.
The product conforms to European Pharmacopoeia specifications.
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CAS Number: 1397-89-3
Molecular Formula: C47H73NO17
Molecular Weight: 924.08
Mechanism of Action: Amphotericin B associates with membrane sterols (ergosterol in fungal cell membranes, and cholesterol in mammalian cell membranes). Amphotericin B forms a pore in these membranes in milleseconds, resulting in leakage of essential ions and ultimately cell death.
Acquired resistance is very low, but is achieved indifferent ways. Some studies with biofilms have found it is due to decrease in ergosterol content and changes in the cell wall.
Amphotericin B can modulates the immune system. It also induces the accumulation of nitric oxide and ROIs.
Storage Conditions: 2-8°C
Tariff Code: 2941.90.1050