产品介绍
| Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody. Subclass: IgG1 Source: Mouse Applications: ELISA, Alphascreen, Fluorescence Polarization, Protein-Lipid Overlay (PIP Strip) Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Storage 2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times. |