Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,3,4-trisphosphate (Ins(1,3,4)P3) is an intermediate in the inositol phosphate pathway. Ins(1,3,4)P3 inhibits Ins(3,4,5,6)P4 1-kinase which regulates Ins(3,4,5,6)P4 levels. Ins(3,4,5,6)P4 in turn is responsible for inhibiting calcium-activated chloride channels. Ins(1,3,4)P3 is produced by dephosphorylation of Ins(1,3,4,5)P4 by a 5-phosphatase. Ins(1,3,4)P3 is a substrate for phosphatases yielding Ins(1,3)P2 and Ins(3,4)P2.
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