PtdIns(3,4,5)P3 3-methylenephosphonate, diC16 (3C-PtdIns(3,4,5)P3, diC16) is a synthetic PI(3,4,5)P3 analog in which the 3-phosphate bond has been rendered metabolically stable as a methylenephosphonate. P-3C916 increases sodium transport across monolayers of cells A6 through activation of GLUT4. |