产品介绍
| PI(3,4,5)P3 diC4 (Phosphatidylinositol 3,4,5-trisphosphate diC4) is a synthetic, purified dibutanoyl PI(3,4,5)P3. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Product Keywords: Dibutanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 (4:0/4:0), PI(3,4,5)P3 (4:0/4:0), or PIP3 Bulk discounts available, please email echelon@echelon-inc.com for information. |