Oleoyl 3-carbacyclic Phosphatidic Acid (ccPA) is an analog of naturally occurring cyclic phosphatidic acid in which the sn-3 oxygen has been replaced with carbon making a stable phosphonate with is resistant to ring opening. ccPA is an analog of LPA but does not activate the LPA1-4 receptors. It also acts as a potent inhibitor of Autotaxin and can inhibit the metastasis of B16-F10 melanoma cells when injected into mice. |