KP372-1 (Akt Inhibitor) ; B-0102 5MG

产品介绍

KP372-1直接抑制Akt、PDK1和Flt3 (Fms样酪氨酸激酶3)的激酶活性，这些激酶在急性髓细胞性白血病(AML)中异常激活。它是一种细胞渗透抑制剂，可降低AML细胞(IC)的集落形成能力50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma. Provided as a 1:1 mixture of regioisomers.