Venturicidin B V018-0.25MG

产品介绍

Venturicidin B (Aabomycin A2) is a 20-member macrolide glycoside compound that was originally isolated from a Streptomyces sp.by Glaxo Labs in 1961. Venturicidin B is a potent antifungal and toxic antibiotic compound, that has also shown cytotoxicity to trypanosomes.

Venturicidin B is a potent inhibitor of bacterial and mitochondrial ATP-synthase complexes acting on the F0 membrane sector, with experiments suggesting that the compound strongly inhibits ATP-driven proton transport and ATP hydrolysis. Venturicidin B demonstrates the ability to drastically decrease the open probability of voltage sensitive K+ channels. Venturicidin B is an inhibitor of ATP5 as well as a potential inhibitor of E. coli H+-ATPase.