TAN 1364B T066-2.5MG

产品介绍

TAN 1364B is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)