Oligomycin E O021-1MG

产品介绍

Oligomycin E (26-hydroxyoligomycin B) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity and mitochondrial toxicity. It can induce apoptosis in a variety of cell types. It is an important bioprobe to study the organization of ATPase on the mitochondrial membrane.  Oligomycin E has weak antibacterial and antifungal activity in comparison to the other Oligomycins.

Oligomycin is a macrolide antibiotic complex from Streptomyces.  It is an inhibitor of mitochondrial F1F0 ATP synthase.  The Oligomycin complex was first reported in 1954, from a strain of Streptomyces diastatochromogenes from soil and highly active against fungi.  The Oligomycin class includes the analogs/isomers A through G.  Different isomers are highly specific for the disruption of mitochondrial metabolism.

Oligomycin can be used to study the mechanistic aspects of ATP formation in tumor cell biology and apoptosis. It can be used to demonstrate ‘proton leak’, the depletion of Δp in the presence of the ATP synthase inhibitor. Useful tool in cytochemistry to study the effects of ATP depletion.

Oligomycin E is soluble in ethanol, methanol, DMSO and DMF.  Practically insoluble in water.