Oligomycin D O020-2.5MG

产品介绍

Oligomycin D (Rutamycin) is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity and mitochondrial toxicity. It can induce apoptosis in a variety of cell types. It is practically free of homologs.  

Oligomycin is a macrolide antibiotic complex from Streptomyces.  It is an inhibitor of mitochondrial F1F0 ATP synthase.  The Oligomycin complex was first reported in 1954, from a strain of Streptomyces diastatochromogenes from soil and highly active against fungi.  The Oligomycin class includes the analogs/isomers A through G.  Different isomers are highly specific for the disruption of mitochondrial metabolism