Oligomycin C O019-1MG

产品介绍

Oligomycin C is a minor analog of a class of macrocyclic lactones isolated from selected strains of Streptomyces spp. It is a non-selective inhibitor of mitochondrial F1F0 ATP synthase in eukaryotes.  Oligomycins exhibit apoptotic cytotoxicity and mitochondrial toxicity. It can induce apoptosis in a variety of cell types. It is practically free of homologs.  

Oligomycin is a macrolide antibiotic complex from Streptomyces.  It is an inhibitor of mitochondrial F1F0 ATP synthase.  Oligomycin is a useful tool in cytochemistry used to study the effects of ATP depletion, or  ‘proton leak’, the depletion of Δp in the presence of the ATP synthase inhibitor.  The Oligomycin complex was first reported in 1954, from a strain of Streptomyces diastatochromogenes from soil and highly active against fungi.  The Oligomycin class includes the analogs/isomers A through G.  Different isomers are highly specific for the disruption of mitochondrial metabolism.  It can also be used as a bioprobe to study the organization of ATPase on the mitochondrial membrane.