Oligomycin A O013-5MG

产品介绍

Oligomycin A is a dominant analog of the Oligomycin class of macrocyclic lactones isolated from selected strains of Streptomyces sp. The class includes the analogs/isomers A through G.  Different isomers are highly specific for the disruption of mitochondrial metabolism.  Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Oligomycin A is an inhibitor of mitochondrial F1F0 ATP synthase.  The Oligomycin complex was first reported in 1954, from a strain of Streptomyces diastatochromogenes from soil which was highly active against fungi.   Oligomycins exhibit apoptotic cytotoxicity and mitochondrial toxicity.