Leptomycin B L004-2.5MG

产品介绍

Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains.  It is a bioactive small molecule with antifungal and antibacterial activity.  It is a nuclear export inhibitor, targeting chromosome region maintenance 1 (CRM1), a nuclear export receptor and a protein in the nuclear export signal (NES) thus can be used as a tool to study nuclear export.  Leptomycin B is an inhibitor of nucleo-cytoplasmic translocation of HIV-1 Rev protein and Rev-dependent mRNA.  It has anti-cancer activity and can modulate cancer-specific pathways.