Ikarugamycin I018-2.5MG

产品介绍

Ikarugamycin is a natural product with an unusual structure, a pentacyclic tetramic acid produced by Streptomyces phaeochromogenes.  Discovered in 1972, the compound belongs to the polycyclic tetramate macrolactams (PTMs) class.  It has potent activity against the protozoan, Trichomonas vaginalis.  It also demonstrates selective Gram-positive antibacterial activity.  In addition, Ikarugamycin inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and Nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis. Importantly, Ikarugamycin is emerging as a useful agent for studying the process of endocytosis.

Ikarugamycin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.