6-Diazo-5-oxo-L-norleucine D106-1MG

产品介绍

6-Diazo-5-oxo-L-norleucine (syn: DON) is a natural antibiotic and glutamine antagonist originally isolated from Streptomyces sp from a Peruvian soil sample in 1954.  The compound has anti-cancer properties, disrupting the mitochondrial internal membrane structures of the neuroendocrine tumor cell line BON and causing DNA single-strand breaks. Prodrug strategies have been developed to enhance delivery of active compound in vivo due to GI toxicity.  It can act synergistically with L-asparaginase to inhibit U251, U87, and SF767 glioblastoma cells. It can be used to study the enzymes that use glutamine such as carbamoyl phosphate synthase and cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminases.