Amicoumacin B A237-0.5MG

产品介绍

Amicoumacin B is a complex antibiotic and isocoumarin produced by Bacillus subtilis. This natural product, a fungal metabolite, is a quorum-sensing inhibitor with activity against Chromobacterium violaceum. It reduces the expression of C. violaceum operons vioA, vioB, VioD, and vioE but increases expression of bioC which indicates quorum sensing inhibitory activity. Its analog, amicoumacin A, has strong anti-inflammatory and anti-ulcer properties in animal models, along with anti-cancer properties. Amicoumacin B is composed of a hydroxyl group and an ester linkage between the hydroxycarboxylic acid moiety and the amino moiety. Amicoumacins belong to a class of dihydroisocoumarin natural products with different members having antibacterial, antifungal, anticancer, and anti-inflammatory activities. The term isocoumarin means these compounds are isomeric to coumarin, which was isolated in 1820 from the tonka tree (formerly Coumarouna odorata). The isocoumarin scaffolds are useful biologically active compounds. Amicoumacin B is soluble in methanol or DMSO.