Voriconazole is a synthetic, second-generation, broad-spectrum triazole antifungal. It is a derivative of fluconazole with increased antifungal activity and specificity. It inhibits ergosterol synthesis, which is the major sterol in fungal cell membranes. The compound is used in the treatment of a broad spectrum of yeasts (including Candida) and molds (including Aspergillus). Voriconazole was patented in 1990 by Pfizer.
Voriconazole is sparingly soluble in ethanol and DMSO.