Trimethoprim ReadyMadeTM Solution T144-1ML

产品介绍

Trimethoprim ReadyMadeTM solution is provided as a sterile-filtered solution of Trimethoprim formulated in DMSO at a concentration of 25 mg/ml. It has been filter-sterilized using a 0.22 μm filter.

Trimethoprim is a synthetic derivative of trimethoxybenzyl-pyrimidine with bacteriostatic and antiprotozoal properties. As a dihydrofolate reductase inhibitor, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid, arresting folic acid synthesis.

When Trimethroprim is combined with sulfonamides, like Sulfamethoxazole (S045), the two compounds show bactericidal effects, but are only bacteriostatic when used separately. The activity is attributed to their synergistic effect in inhibiting folic acid metabolism in bacteria.