Ticarcillin Disodium USP T034-1G

产品介绍

Ticarcillin disodium, USP is an extended-spectrum (4th generation) β-lactam in the carboxypenicillin family. Ticarcillin Disodium (BRL 2288) was originally synthesized by Beecham Research Laboratories in 1967 and was made available for research, prior to 1970. Ticarcillin has bactericidal activity against many gram-positive and gram-negative bacteria, particularly Pseudomonas aeruginosa.

Ticarcillin Disodium is a cell wall synthesis inhibitor. It exerts bactericidal activity via inhibition of bacterial cell wall biosynthesis at the level of peptidoglycan cross-linking by inhibiting peptidoglycan transpeptidases.

In molecular biology, ticarcillin is used to as an alternative to Ampicillin Sodium (A042) to test the uptake of marker genes into bacteria. It prevents the appearance of satellite colonies that occur when ampicillin breaks down in the media. It is also used in plant molecular biology to kill agrobacterium, which is used to deliver genes to plant cells.

TOKU-E offers two forms of ticarcillin disodium: Ticarcillin Disodium (T027) and Ticarcillin Disodium w/ Clavulanate Potassium (Timentin) (T020). Both forms are freely soluble in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes, preventing them from breaking down β-lactam antibiotics. Ticarcillin disodium can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.

Ticarcillin Disodium, USP conforms to United States Pharmacopeia specifications.