Tazobactam T001-1G

产品介绍

Tazobactam is a penicillanic acid sulfone derivative and β-lactamase inhibitor with antibacterial activity. Tazobactam was discovered by Dr. R.G. Micetech at the University of Alberta in 1982. Tazobactam contains a β-lactam ring and irreversibly binds to β-lactamase at or near its active site. This protects other β-lactam antibiotics from β-lactamase catalysis. This drug is used in conjunction with β-lactamase susceptible penicillins to treat infections caused by β-lactamase producing organisms.

Tazobactam alone showed an MIC of ≤ 8 mg/liter (range 2 to 32 mg/liter) against several Acinetobacter baumannii strains. Tazobactam in combination with piperacillin, successfully restored the activity of piperacillin against β-lactamase-producing bacteria. Tazobactam exhibited inhibitory activity and protected piperacillin against Richmond and Sykes types II, III, IV and V β-lactamases, staphylococcal penicillinase and extended-spectrum β-lactamases. Tazobactam showed species-specific activity against class I chromosomally-mediated enzymes.

Tazobactam is slightly soluble in aqueous solution.