Streptomycin ReadyMade™ Solution S139-10x1ML

产品介绍

Streptomycin ReadyMadeTM Solution is provided as a sterile-filtered solution of Streptomycin Sulfate formulated in water at a concentration of 100 mg/ml. It has been filter-sterilized using a 0.22 μm filter.

Streptomycin is an aminocyclitol glycoside antibiotic discovered by Salman Waksman, Albert Schatz, and Elizabeth Bugie at Rutgers University in 1943 and patented in 1948. Streptomycin is isolated from Streptomyces griseus and shows bacteriostatic activity at low concentrations and bactericidal activity at higher concentrations against mycobacteria and Gram-negative bacteria. It is less active against Gram-positive bacteria.  Streptomycin Sulfate has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus species; a glycopeptide antibiotic resistant "superbug”.

Streptomycin is a protein synthesis inhibitor that acts by binding to the 30S ribosomal subunit at the S12 protein thereby inducing a misreading of the genetic code, inhibiting the initiation of translation of DNA, which then results in death for a susceptible bacterium. Streptomycin has also shown activity as a miRNA inhibitor, that is capable of down-regulating miR-21, a miRNA that is overexpressed in a wide variety of cancers.