CL-11-S1PR1 ; Sphingosine-1-phosphate Receptor 1 (S1PR1) Stable Cell Line

产品介绍

Name Sphingosine-1-phosphate Receptor 1 (S1PR1) ACTOneTM Stable Cell Line Description This cell line is a HEK-293-CNG cell line that expresses a recombinant human S1PR1. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader. Application cAMP dependent assay for Gi-coupled human S1PR1; cell-based high-throughput screening of human S1PR1 inhibitors. Size 1x 106 cells Detection FlexStation or Microplate reader