CL-01-HTR4 ; 5-Hydroxytryptamine (Serotonin) Receptor 4 (HTR4) Stable Cell Line

产品介绍

Name 5-Hydroxytryptamine (Serotonin) Receptor 4 (HTR4)  ACTOneTM Stable Cell Line Description This cell line is a HEK-293-CNG cell line that expresses a recombinant human HTR4. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader. Application cAMP dependent human HTR4 cell-based assay; Cell-based high-throughput screening (HTS) of human HTR4 agonists/antagonists Size 1 mL (frozen cells; 1x 106 cells before freezing) Detection FlexStation or Microplate reader