产品介绍
Sulfadiazine sodium is a sulfonamide antibiotic that was developed in 1940 by Richard Roblin at the Stamford Research Laboratories of the American Cyanamid Company to be a more potent and less toxic alternative to Sulfapyridine. Sulfadiazine is a bacteriostatic folic acid synthesis inhibitor that shows broad spectrum activity against gram-positive bacteria, gram-negative bacteria and Chlamydia.
Sulfadiazine sodium is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Sulfadiazine sodium dissolves freely in water (50mg/mL).
Synonyms: 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide sodium salt, N1-(Pyrimidin-2-yl)sulfanilamide sodium