Name Adenosine A1 Receptor (ADORA1) ACTOneTM Stable Cell Line Description This cell line is a HEK-293-CNG cell line that expresses a recombinant human ADORA1. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR or a fluorescence microplate reader. Application cAMP dependent human ADORA1 cell-based assay; cell-based high-throughput screening of human ADORA1 agonists/antagonists. Size 1 mL (frozen cells; 1x 106 cells before freezing) Detection FlexStation or Microplate reader |