Salinomycin S001-5MG

产品介绍

Salinomycin (syn: Coxistal, Coxistac) is a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the research division of Kaken Chemical Co. in Tokyo Japan.

Salinomycin affects cell membrane permeability by increasing cation movement across cell membranes through exchange-diffusion, resulting in altered gradients due to a lack of control of ion permeability. This allows ions (K+, Na+, Ca+, Mg2+) to accumulate inside the cell, reaching toxic levels.  Salinomycin is effective against Gram-positive bacteria including mycobacteria, some filamentous fungi, and coccidia.

Salinomycin has been shown to induce apoptosis in a variety of cancer cell lines and to inhibit multidrug resistance protein 1.

Salinomycin is slightly soluble in methanol but practically insoluble in water.