Rapamycin R001-10MG

产品介绍

Rapamycin (Sirolimus) is a natural compound belonging to the macrolide family.  It is derived from Streptomyces hygroscopicus isolated from a soil sample from Easter Island in 1972 by Mr. Sehgal of Ayerst Research Labs in Montreal, Quebec.  It was named Rapamycin after the native name for Easter Island, Rapa Nui.   It is active against fungi and yeast but was found to have immunosuppressive and anti-cancer properties.  It is marketed under the trade name Rapamune by Pfizer (formerly Wyeth).  Rapamycin provided the stimulus for research on the pivotal mTOR pathway that controls a range of biological processes.  Deregulation of the mTOR pathway is implicated in diseases like cancer, diabetes and obesity.  The poor solubility and pharmacokinetics of Rapamycin triggered the development of several Rapamycin analogs (rapalogs) such as temsirolimus, everolimus, and ridaforoliumus. 

Rapamycin is soluble in DMSO and ethanol, but practically insoluble in water.