Nisin N013-1G

产品介绍

Nisin (Nisin A) is a natural bacteriocin polypeptide antibiotic known as a lantibiotic. It is a 34-amino acid polycyclic antibacterial peptide.  It was isolated in the late 1930s from Lactococcus lactis.  Nisin A and Nisin Z are two naturally occurring variants of Nisin that differ by a single amino residue at position 27 (Nisin A=histidine; Nisin Z=asparagine).

Nisin is a proteinaceous toxin produced by Gram-positive bacteria to reduce competitive strain from other Gram-positive bacteria and it has bactericidal properties.  It is used as a selective agent in microbiological media to isolate Gram-negative bacteria, yeast, and molds.  It commonly used a food additive to prevent spoilage.

Nisin has been found to have anti-cancer properties in head and neck squamous cell carcinoma (HNSCC), breast cancer, and colon cancer model systems and thus is a promising agent for the development as a cancer therapeutic agent given its efficacy in vitro and in vivo, and non-toxic properties.  Nisin is water-soluble.